Dr. Connors was mentioned briefly in the film Spider-Man (2002) as Peter's laboratory supervisor who fired him for being late. Connors appeared in the sequels Spider-Man 2 (2004) and Spider-Man 3 (2007), where he was played by actor Dylan Baker. Unlike in the comics, Dr. Connors did not become the Lizard in this franchise, however, he is missing his right arm as in the comic book.
In Spider-Man 2, Connors is depicted as a Columbia University physics professor concerned for Peter Parker's well-being and academic performance in his quantum mechanics course. Peter is seen studying with several textbooks for this course, two of which can be made out as quantum mechanics and photonics books. Curt's friend, Doctor Otto Octavius, recalls Peter's name and tells Peter that Connors considers him "brilliant, but lazy". Otto chuckles about his friend's assumption regarding Peter's laziness once he finds out Peter is also Spider-Man.
In Spider-Man 3, Dylan Baker reprises his role as Dr. Connors. He is once again Peter's quantum mechanics professor in this film, which suggests it might be the same semester as, or a continuation of the course, shown in Spider-Man 2, though a different classroom full of new students is shown. Also in this film, Peter turns to Connors to analyze the substance of the Venom symbiote and Connors informs him that it makes one more aggressive and that it has a particular liking for him. At one point during this scene, Connors says, "I'm a physicist, not a biologist", which contradicts the origins of Connors' lizard-related research from the comic books.